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Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you should err on the side of caution and allow FDA do its job and demand some research be done so that the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on their own medications. Researchers found that participants using this drug to get a year, dropped excess weight within four weeks and have kept the weight off through the 56 weeks from the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more effective and safer. Combo-pilling could be the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that since right now there aren't any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. From a psychiatric viewpoint, evidence shows that the ordinary neural mechanism for goal-directed behavior has become hijacked by the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus and also the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).