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Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err assisting caution and let the FDA do its job and demand some study be done so that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to make money and that they would say anything to keep people on their own medications. Researchers found that participants taking this drug for a year, dropped a few pounds within 4 weeks and have kept the extra weight off throughout the 56 weeks in the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them more efficient and safer. Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that by right now there aren't long term prescription weightloss pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug could also raise hypertension and heartrate, and really should not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and pulse rate and must 't be used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.